Integrating basic science with translational research: the 13th International Podocyte Conference 2021Short communication Published on 2022-10-012022-10-05 Journal: Kidney international [Category] 비임상, [키워드] 13th International Podocyte Conference Abstract addition Basic science Clinicians Conference coronavirus disease COVID-19 Day Diagnosis global pandemic introduced meeting report offered pandemic pathway Patient patients podocyte podocyte2021 Research researcher researchers Resilience selected Therapies translational [DOI] 10.1016/j.kint.2022.07.021 [Article Type] Short communication
JAK inhibitor blocks COVID-19 cytokine-induced JAK/STAT/APOL1 signaling in glomerular cells and podocytopathy in human kidney organoidsJAK 억제제는 사구체 세포에서 COVID-19 사이토카인 유도 JAK/STAT/APOL1 신호전달 및 인간 신장 오르가노이드에서 족세포병증을 차단합니다Article Published on 2022-06-082022-09-11 Journal: JCI Insight [Category] COVID19(2023년), MERS, SARS, 유전자 메커니즘, 진단, [키워드] abundantly expressed alleles APOL1 Baricitinib best block blocked capillary carried carrier cause Cell Cell Biology cells collapse controls COVID-19 COVID-19 infection cytokine Cytokines demonstrated Endothelial cell endothelial cells expression glomerular glomerular capillaries human kidney Infection inhibitor iPS cells. JAK inhibitor jak inhibitors JAK/STAT JAK/STAT pathway JAK/STAT signaling JAK1 kidney Kidney disease knowledge majority mechanism Nephrology nephropathy Organoid organoids pathogenic Patient phenotype podocyte Podocytes Protein reduced rescued resulting risk SARS-CoV-2 Signaling STAT Support Therapeutic benefit therapeutic benefits Trigger viability [DOI] 10.1172/jci.insight.157432 PMC 바로가기 [Article Type] Article
ScoMorphoFISH: A deep learning enabled toolbox for single-cell single-mRNA quantification and correlative (ultra-)morphometryArticle Published on 2022-06-012023-07-09 Journal: Journal of Cellular and Molecular Medicine [Category] COVID19(2023년), [키워드] Kidney biopsy podocyte Renal pathology SARS-CoV-2 super-resolution microscopy. [DOI] 10.1111/jcmm.17392 PMC 바로가기
Long-term cardio-vascular risk assessment in chronic kidney disease and kidney transplanted patients following SARS-COV-2 disease: protocol for multi-center observational match controlled trial만성 신장 질환 및 SARS-COV-2 질환에 따른 신장 이식 환자의 장기 심혈관 위험 평가: 다기관 관찰 일치 대조 시험 프로토콜Article Published on 2022-05-062022-09-11 Journal: BMC Nephrology [Category] COVID19(2023년), SARS, 임상, [키워드] Acute kidney injury acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 affecting angiotensin Angiotensin-converting enzyme association binding Biomarkers blood vessels Cardiac complications Cardio-vascular risk cardiovascular cardiovascular disease caused chronic Chronic kidney disease CKD clinical evaluation control group Controlled trial coronavirus coronavirus disease COVID-19 COVID-19 disease CVD database de novo death determine dialysis dialysis. disease echocardiographic parameters Endothelial cell endothelial cells Endothelial dysfunction enrolment epithelial cells expected expressed focus heart higher risk implication incidence investigator investigators kidney Kidney disease kidney transplant lung mechanism multi-organ failure outcomes pandemic Patient patients pericyte pericytes podocyte produced protocol proximal pulse Pulse wave pulse wave velocity Registered renal risk risk factor SARS-CoV-2 SARS-COV-2 infection Sepsis severe acute respiratory syndrome Coronavirus severe disease Shock the disease therapeutic options Trial worse prognosis [DOI] 10.1186/s12882-022-02809-4 PMC 바로가기 [Article Type] Article
Collapsing Focal Segmental Glomerulosclerosis in Viral Infections바이러스 감염에서 국소 분절 사구체 경화증의 붕괴Review Published on 2022-01-132022-09-11 Journal: Frontiers in Immunology [Category] 변종, 유전자 메커니즘, [키워드] activated Acute kidney injury acute viral infection acute viral infections African AKI APOL 1 APOL1 appearance Capillaries cascade cellular characterized Collapsing contributing to COVAN COVID-19 cytokine cytomegalovirus described direct viral infection drug epithelial cells etiologies Evidence Focal focal segmental glomerulosclerosis focus function glomerular glomerular capillaries glomerulopathy glomerulosclerosis hemodynamic instability high risk HIV HIVAN hyperplastic hypertrophic immune response immune responses impairment Infection Injury Ischemia kidney Kidney disease Kidney failure knowledge obliteration Pathogenesis Patient podocyte Podocytes potential mechanism potential mechanisms progression Proteinuria renal epithelial cell risk SARS-CoV-2 SARS-COV-2 infection Segmental Severe case severe cases systemic immune response systemic immune responses systemic inflammatory variant Viral viral entry viral infection viral infections [DOI] 10.3389/fimmu.2021.800074 PMC 바로가기 [Article Type] Review
Acute Kidney Injury in COVID-19Review Published on 2021-07-282022-10-29 Journal: International Journal of Molecular Sciences [Category] COVID-19, SARS, [키워드] ACE2 Acute kidney injury AKI association cells Clinical features Collapsing COVID-19 COVID-19 patients Cytokine storm dialysis entry of SARS-CoV-2 enzyme Hospitalization human cells Hypovolemia investigated kidney kidney damage Kidney injury knowledge management Mortality Pathomechanism podocyte proximal tubular cells recent receptor renal renal replacement therapy Respiratory illness Risk factors RRT SARS-CoV-2 SARS-COV-2 infection viral infection [DOI] 10.3390/ijms22158081 PMC 바로가기 [Article Type] Review
The glomerular filtration barrier: a structural target for novel kidney therapies Reviews Published on 2021-07-142022-10-05 Journal: Nature Reviews Drug Discovery [Category] 바이오마커, [키워드] Affect APOL1 Cell cells characterized component contractile contribute CoQ10 disease diuretics endothelial experiment genetics glomerular filtration growth factor homologue Immunosuppressive agents include inhibitor Intercellular communication intervene kidney Kidney disease Kidney function Loss maintain Mitochondrial function molecular target morbidity and mortality MOST podocyte question receptor review ROBO2 suPAR surface receptor therapy treated tyrosine Vascular [DOI] 10.1038/s41573-021-00242-0 [Article Type] Reviews
Metabolic Alterations in SARS-CoV-2 Infection and Its Implication in Kidney DysfunctionPhysiology Published on 2021-02-252022-10-31 Journal: Frontiers in Physiology [Category] COVID-19, [키워드] Acute kidney injury acute respiratory syndrome alteration Cell cell metabolism change clinical conditions COVID-19 Critical develop effective epithelial cells etiological agent event expected fat acid oxidation Glucose Glycolysis host response induce Inflammation kidney kidney dysfunction Kidney injury mechanism metabolic metabolic disorder metabolism organ dysfunction outbreak pathogen pathogenic virus Perspective phenotype podocyte progression promote provoke proximal raised renal SARS-CoV-2 SARS-COV-2 infection severe coronavirus disease severity survival sustained the disease tissue injury Treatment tubular epithelial cells viral infection virus [DOI] 10.3389/fphys.2021.624698 PMC 바로가기 [Article Type] Physiology
Does SARS-CoV-2 Infect the Kidney?Article Published on 2020-12-012023-07-06 Journal: Journal of the American Society of Nephrology : JA [Category] SARS, [키워드] ACE2 AKI COVID-19 podocyte proximal tubule. [DOI] 10.1681/ASN.2020081229 PMC 바로가기
Glomerular filtration barrier dysfunction in a self-limiting, RNA virus-induced glomerulopathy resembles findings in idiopathic nephrotic syndromesArticle Published on 2020-11-052022-10-04 Journal: Scientific Reports [Category] 바이오마커, [키워드] albumin levels analysis analyzed Biomarker Concentration correlated correlated strongly described disease dysfunction filtration generate glomerular glomerular diseases hantavirus healthy controls IgG IgG level Immunoglobulin Infection Injury INS involved marker Mild nephrin pathophysiological Patient patients podocyte Podocytes receptor regenerative renal reveal RNA serum Serum level significantly significantly higher significantly increased suPAR syndrome therapeutic approach unique viral infection [DOI] 10.1038/s41598-020-76050-0 PMC 바로가기 [Article Type] Article